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Accueil > Séminaires

Salle de réunion bat. LWOFF

Lundi 27/10 - 10h30

Pr. Ilan Rosenshine (The Hebrew University, Jerusalem)
Title : The stealth strategy of enteropathogenic E. coli

The group of Pr. Rosenshine investigates the molecular cross-talk between pathogenic bacteria and mammalian host cells. The host employ intricate array of systems to neutralize, eliminate and kill the intruding bacteria. In response, pathogens make use of their virulence machinery to evade and interfere with the host defences and to attack the host cells. Key virulence machinery is a surface organelle termed type III protein secretion system (TTSS). The TTSS is a nano-syringe, employed by pathogens to inject into the host cell a battery of proteins termed “effectors”. The injected effectors function in concert to subvert host processes to benefit the pathogen. Pr. Rosenshine focuses mainly on entropathogenic E. coli (EPEC) and it’s TTSS, which is essential for virulence and one of the best studied TTSSs.
Pr. Rosenshine will talk about how the bacteria employ TTSS effector to modulate the two main innate immune signaling pathways ; MAP kinase and NF-kB. In addition he will relate it to the dynamics of effector translocation.