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CNRS INSA de Lyon Université Lyon1

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Accueil > Séminaires

Salle de réunion bat. LWOFF

vendredi 22/05/15 - 11h

Axel Magalon, LCB, Marseille

"From respiratory complex assembly to bacterial respiration optimization"

Résumé : Oxidative phosphorylation (OXPHOS) is an essential process for most living organisms sustained by multisubunit complexes anchored in the lipid bilayer. The basic principle of OXPHOS applies to the respiratory electron transfer chains of eukaryotes and prokaryotes. Plasticity is a hallmark of the OXPHOS process. In eukaryotes, mitochondria are dynamic compartments fine-tuning their activity in response to changes in nutrient avaibility and oxygen concentrations through a plastic organization of the OXPHOS complexes in the membrane. Such a plastic organization consists in a balanced distribution between isolated complexes and supercomplexes. Similarly, prokaryotes are characterized by the coexistence of several complexes both at the electron input and output leading to multiple electron transfer routes. Such a metabolic flexibility accounts for colonization of multiple environments and adaptation to environmental changes. An immediate question concerns the cellular organization of OXPHOS in living organisms i.e. how are distributed the complexes across the membrane ? Is there a dynamic distribution ? Furthermore, does such organization have functional implications ?
Here, I will address several fundamental questions ranging from how to assemble a respiratory complex to optimization of the bacterial respiration process using Escherichia coli as a model system.