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Vendredi 10 Mars - 11h00

Séminaire de Guillaume Tétreau, UPVD, Université de Perpignan, Laboratoire Interactions Hôtes-Pathogènes-Environnements (invité par Yvan Rahbé)

Salle de réunion bat. Lwoff, sous-sol.


Invertebrate immunity has been studied for decades, especially on few model insect species, and several pathways (Toll, Imd, JAK/STAT, etc.) have been identified. Although extensively investigated, many details of the host-pathogen interaction processes remain largely unknown. For example, the very first step of any host immune response is the recognition of proteins from the infecting pathogens to trigger the appropriate response. Despite its key role in both the specificity and the efficacy of the immune response, a lot of recognition molecules with contrasted functions are clustered together into a “black box” named Pathogen Recognition Patterns (PRP). Moreover, the transmissible aspect of the immunity, from an exposed mother to a naïve progeny, has only been recently identified and named Trans-Generational Immune Priming (TGIP) but the molecular mechanisms at play are yet to be unraveled. During this presentation, I will present an extensive overview of TGIP, with a focus on the potential mechanisms identified to date, and I will describe a new technique that we developed to detect all molecules that are implicated in the recognition of a pathogen. This technique provides new insights into the specificity of the host immune response towards different pathogens and allows identifying new and somewhat surprising potential actors of pathogens recognition process. Finally, I will focus on one specific family: aerolysin-like proteins. These proteins, acquired by invertebrates from bacteria are homologs to pore- forming toxins and they possess a dual function, being both receptors and effectors, and they might be at the basis of the specificity of the innate and adaptive invertebrate immune response.